d-Glucose Suppression of Tyrosine Aminotransferase in Rat-Hepatoma Cells Grown in Culture
نویسندگان
چکیده
منابع مشابه
Alteration of tyrosine aminotransferase activity in hepatoma cells in tissue culture by amphotericin B.
Two clonal lines of rat hepatoma cells, in tissue culture, that have steroid-inducible tyrosine aminotransferase (TAT) activities were shown to have different responses to amphotericin B. One of the cell lines (HTC) was relatively resistant to the growth-inhibiting effects of amphotericin B and demonstrated an inhibition of only its steroid-inducible TAT activity when exposed to the antifungal ...
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In the Reuber (H35) hepatoma cell strain, microsomal aryl hydrocarbon (benzo[a]pyrene) hydroxylase is induced 25-fold by the polycyclic hydrocarbon benz[a]anthracene but is not induced by the steroid hormone dexamethasone. Soluble tyrosine aminotransferase is induced sixfold by dexamethasone and twofold by benz[a]anthracene. Each enzyme requires similar inducer concentrations for induction, and...
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Glucocorticoid receptors with many properties suggesting their involvement in the hormonal induction of tyrosine aminotransferase have been detected in rat hepatoma tissue culture cells. These "specific receptors" approach saturation as the steroid concentrations required for maximal induction are reached. Inducer analogs influence cortisol binding to the specific receptors in direct relation t...
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The incorporation of methyl-labeled choline into phosphorylcholine and phosphatidylcholine of cellular membranes by Novikoff rat hepatoma cells (line N1S1-67) during growth in suspension culture was investigated. Upon initiation of a fresh culture at 10(5) cells/ml, the rate of synthesis of phosphorylcholine by the cells was four to five times greater than that of the synthesis of phosphatidylc...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1971
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1971.tb19664.x